In this series of six videos, you’ll discover more about PRISM and its aims!
PRISM is an acronym that stands for “Psychiatric Ratings using Intermediate Stratified Markers: providing quantitative biological measures to facilitate the discovery and development of new treatments for social and cognitive deficits in Alzheimer’s disease, Schizophrenia, and major depression.
Understanding the neurobiology of many neuropsychiatric disorders – such as schizophrenia, major depression and Alzheimer’s – will require novel quantitative biological approaches. Currently, clinical diagnosis is still dependent on the convention-based clustering of qualitative clinical symptoms.
The PRISM consortium is implementing an innovative transdiagnostic approach to link symptoms to biology using a quantitative approach and in doing so to accelerate the discovery and development of new and better treatments for patients.
In the first video Martien Kas, the project co-ordinator, introduces the project.
In this second video, you will discover how PRISM implements innovative (digital) technologies, such as the smartphone app BEHAPP, to assess social withdrawal and other behaviours in Schizophrenia, major depression and Alzheimer’s patients.
In this third video, Martien Kas, the PRISM project co-ordinator, explains how the project will increase our neurobiological knowledge and improve predictive model systems for Schizophrenia, major depression and Alzheimer’s, to accelerate the drug discovery process.
PRISM aims to understand the neurobiological basis underlying social and cognitive deficits that are common across neuropsychiatric disorders. Measuring neuronal activity through EEG is one of the technologies used by project to investigate the neurobiological basis. Discover more in this fourth video of the PRISM series.
To identify which biological substrates are affected in the brain, PRISM is investigating the morphology and activity of neural circuits using neuroimaging approaches in patients and animals. Discover more in this fifth video of the PRISM series.
In this last video of the series, Martien Kas, the PRISM project co-ordinator, will provide an overall view of the project, including what the project would like to deliver to accelerate the discovery and development of better treatments for patients.